New Insights On The Carotid Body's Role In Blood Pressure
Researchers at the University of Auckland have identified a potential new factor in managing high blood pressure. Their focus is on the carotid body, a small organ in the neck, which may be key in controlling heart attack and stroke risks.
The carotid body, known for its role in regulating breathing during low-oxygen conditions, has now been linked to high blood pressure. Through studies on rats, scientists found that the carotid body activates the sympathetic nervous system under high blood pressure, similar to the 'fight or flight' response. This discovery was detailed in Circulation Research.
Dr. Audrys Pauza, leading the research, explains that this finding may clarify why some individuals remain at high risk for cardiac issues even after their high blood pressure is treated. Pauza uses an analogy: lowering blood pressure is like braking a speeding car, but without addressing the carotid body's influence, it's like not easing off the accelerator.
Currently, there are medications available that target the human carotid body. However, further research is needed to confirm if humans react similarly to rats. Professor Julian Paton from the University’s Manaaki Manawa, Centre for Heart Research, notes that previous studies show the carotid body's activity is stimulated by the same mechanisms in both species, offering hope for future treatments.
Understanding the carotid body's role in blood pressure regulation could lead to more effective treatments for preventing heart attacks and strokes. If this organ can be successfully targeted, it might enhance the current approach to managing cardiovascular health.
While these findings are promising, further investigation is needed to confirm their applicability to human health. This includes verifying the rat model results in humans and ensuring the safety and efficacy of potential treatments.